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Lovelace-CRCE Project 5: Models to Assess Efficacy of Countermeasures for SM-Induced Toxicity
The overall objective of this project is to identify the most efficacious therapeutics to treat Sulfur Mustard- (SM-) induced toxicity. The specific goals of this research project are to establish validated models of SM toxicity following inhalational, dermal, and ocular exposure. Once these models are established, the efficacy of existing therapeutics and potential new therapeutics to attenuate SM-induced toxicity identified in Research Projects 2, 3, and 4 will be examined.
The efficacy of new formulations and alternative routes of therapeutic delivery (i.e., inhalation vs. injected or oral) will also be examined. Formulations and dose routes showing the most promise for therapeutic efficacy will undergo more definitive efficacy evaluations conducted under Good Laboratory Practice Guidelines to support any future Investigational New Drug Applications to the U.S. Food and Drug Administration (FDA). These proposed studies are significant because they will identify and provide definitive efficacy studies on new therapeutics or alternate formulations of existing therapeutics for the treatment of SM-induced toxicity.
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